Abstract
Activation of imines by hydrogen bonding is a very powerful way of promoting the synthesis of a variety of nitrogencontaining compounds of interest. Such a useful approach typically involves mild reaction conditions, simple experimental operations and metal-free reagents. The present review focuses on the recent development of new organocatalytic methods involving imines and related compounds as substrates in which activation through hydrogen bonding is performed. The different modes of activation are thoroughly illustrated with special emphasis on mechanistic aspects of the reactions and how activation is actually produced.
Keywords: Imines, organocatalysis, hydrogen-bond, bronsted acids, thioureas, phosphoric acids, Knoevenagel condensation, LUMO activation, HOMO activation), chalcogenides, BRONSTED CATALYSIS, SINGLE HYDROGEN-BONDING, peptidomimetics, cinchonine, enantioinduction
Current Organic Chemistry
Title: Organocatalytic Activation of Imines and Related Compounds Through Hydrogen-Bond Interactions
Volume: 15 Issue: 13
Author(s): Pedro Merino, Ignacio Delso, Tomas Tejero, David Roca-Lopez, Aranzazu Isasi and Rosa Matute
Affiliation:
Keywords: Imines, organocatalysis, hydrogen-bond, bronsted acids, thioureas, phosphoric acids, Knoevenagel condensation, LUMO activation, HOMO activation), chalcogenides, BRONSTED CATALYSIS, SINGLE HYDROGEN-BONDING, peptidomimetics, cinchonine, enantioinduction
Abstract: Activation of imines by hydrogen bonding is a very powerful way of promoting the synthesis of a variety of nitrogencontaining compounds of interest. Such a useful approach typically involves mild reaction conditions, simple experimental operations and metal-free reagents. The present review focuses on the recent development of new organocatalytic methods involving imines and related compounds as substrates in which activation through hydrogen bonding is performed. The different modes of activation are thoroughly illustrated with special emphasis on mechanistic aspects of the reactions and how activation is actually produced.
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Cite this article as:
Merino Pedro, Delso Ignacio, Tejero Tomas, Roca-Lopez David, Isasi Aranzazu and Matute Rosa, Organocatalytic Activation of Imines and Related Compounds Through Hydrogen-Bond Interactions, Current Organic Chemistry 2011; 15 (13) . https://dx.doi.org/10.2174/138527211796150660
DOI https://dx.doi.org/10.2174/138527211796150660 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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