Role of Stem Cells in Normal Liver and Cancer

Author(s): Chi Keung Lau, Zhen Fan Yang, Sheung Tat Fan

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 11 , Issue 6 , 2011

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Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, and the idea of targeting CSCs sheds light on more effective therapeutic strategies for HCC. In this review, normal stem cells and putative CSCs in the liver are briefly introduced. Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed.

Keywords: Normal stem cells, cancer stem cells, hepatocellular carcinoma, Epidemiology, chemoembolization, angiogenesis, hydrolase, EpCAM, CD13, CD90, NOTCH, OVAL CELLS, PTEN, TGF

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Article Details

Year: 2011
Page: [522 - 528]
Pages: 7
DOI: 10.2174/187152011796011091
Price: $65

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PDF: 131