Oral Lipid Based Drug Delivery System (LBDDS): Formulation, Characterization and Application: A Review

Md.      Akhlaquer Rahman; Ranjit      Harwansh; Mohd.      Aamir Mirza; Sarfaraj      Hussain; Arshad      Hussain

Abstract

The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variability, lack of dose proportionality and therapeutic failure. The improvement of bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations. Oral lipid based formulations are attracting considerable attention due to their capacity to increase the solubility, facilitating gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water soluble, lipophilic drug and thus increasing the bioavailability. The present review outlines the recent findings on selfemulsifying drug delivery system (SEDDS), self-micro/nanoemulsifying drug delivery system (SMEDDS/SNEDDS) and evaluation of these formulations published over the past decade. The application of lipid based formulations as a promising system for the oral delivery of many therapeutic agents including traditional medicine (TM) has also been examined in the current review.

Keywords: Self-Micro/Nanoemulsifying drug delivery system (SMEDDS/SNEDDS), Solubility, Bioavailability, Oral absorption, Surfactant, Co-surfactant, LBDDS, Cyclosporin A, specific absorption, Digestion of lipids