Abstract
After years of viewing cirrhosis as the irreversible end-stage of liver fibrosis, it has been shown recently that the possibility of its reversal is no longer a dream. Several studies on experimental animal models showed possible spontaneous resolution of fibrosis after the removal of fibrogenic stimulus. Similar results were also observed in human patients with liver fibrosis due to autoimmune hepatitis and biliary etiology. However, the need for other means of treatment is urgent, especially when the removal of the causative factor is unlikely. Recent antifibrotic strategies were designed to target one or more of the three stages involved in the process of fibrosis. These are the triggering stage, fibrogenesis, and extracellular matrix accumulation. In this review, the classification of the current drugs or agents that showed inhibition of one or more of fibrosis stages with their chemical synthesis are presented.
Keywords: Antifibrotics, fibrosis, cirrhosis, fibrogenesis, extracellular matrix accumulation, epigenetic therapy, Hepatic stellate cells (HSC), fibrogenesis inhibitors, MMPs, Prolyl-4-hydroxylase, fibrogenesis triggers
Current Medicinal Chemistry
Title: Current Progress in Antifibroitcs
Volume: 18 Issue: 20
Author(s): S. A.A. El Bialy, K. F. Abd El Kader and M. B. El-Ashmawy
Affiliation:
Keywords: Antifibrotics, fibrosis, cirrhosis, fibrogenesis, extracellular matrix accumulation, epigenetic therapy, Hepatic stellate cells (HSC), fibrogenesis inhibitors, MMPs, Prolyl-4-hydroxylase, fibrogenesis triggers
Abstract: After years of viewing cirrhosis as the irreversible end-stage of liver fibrosis, it has been shown recently that the possibility of its reversal is no longer a dream. Several studies on experimental animal models showed possible spontaneous resolution of fibrosis after the removal of fibrogenic stimulus. Similar results were also observed in human patients with liver fibrosis due to autoimmune hepatitis and biliary etiology. However, the need for other means of treatment is urgent, especially when the removal of the causative factor is unlikely. Recent antifibrotic strategies were designed to target one or more of the three stages involved in the process of fibrosis. These are the triggering stage, fibrogenesis, and extracellular matrix accumulation. In this review, the classification of the current drugs or agents that showed inhibition of one or more of fibrosis stages with their chemical synthesis are presented.
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Cite this article as:
A.A. El Bialy S., F. Abd El Kader K. and B. El-Ashmawy M., Current Progress in Antifibroitcs, Current Medicinal Chemistry 2011; 18 (20) . https://dx.doi.org/10.2174/092986711796391679
DOI https://dx.doi.org/10.2174/092986711796391679 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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