Abstract
Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of their discovery, 1960s – 1970s, the general mindset was that free radicals in biology must be damaging. Indeed SOD blunts the cascade of oxidations initiated by superoxide. However in the late 1970s it was observed that cancer cells that have low activity of the mitochondrial form of SOD, MnSOD, grow faster than those with higher activities of MnSOD. These observations indicated that SOD, superoxide, and hydrogen peroxide affected the basic biology of cells and tissues, not just via damaging oxidation reactions. It is now realized that superoxide and hydrogen peroxide are essential for normal cellular and organism function. MnSOD appears to be a central player in the redox biology of cells and tissues.
Keywords: Superoxide dismutase, mitochondria, coenzyme Q, hydrogen peroxide, superoxide, redox environment, hypoxia inducible factor, iron, melanoma cells, reduction, xanthine oxidase, tocopherol, low-flux signaling circuits, hypoxia, histidines
Anti-Cancer Agents in Medicinal Chemistry
Title: Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide
Volume: 11 Issue: 4
Author(s): Garry R. Buettner
Affiliation:
Keywords: Superoxide dismutase, mitochondria, coenzyme Q, hydrogen peroxide, superoxide, redox environment, hypoxia inducible factor, iron, melanoma cells, reduction, xanthine oxidase, tocopherol, low-flux signaling circuits, hypoxia, histidines
Abstract: Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of their discovery, 1960s – 1970s, the general mindset was that free radicals in biology must be damaging. Indeed SOD blunts the cascade of oxidations initiated by superoxide. However in the late 1970s it was observed that cancer cells that have low activity of the mitochondrial form of SOD, MnSOD, grow faster than those with higher activities of MnSOD. These observations indicated that SOD, superoxide, and hydrogen peroxide affected the basic biology of cells and tissues, not just via damaging oxidation reactions. It is now realized that superoxide and hydrogen peroxide are essential for normal cellular and organism function. MnSOD appears to be a central player in the redox biology of cells and tissues.
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Cite this article as:
R. Buettner Garry, Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (4) . https://dx.doi.org/10.2174/187152011795677544
DOI https://dx.doi.org/10.2174/187152011795677544 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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