Abstract
Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are diseases of tropical and subtropical countries causing considerable morbidity. The available control strategies have significant limitations such that current drugs are ineffective against macrofilariae (adult worms), require repeated and prolonged treatment over years and are threatened by emergence of drug resistance. Due to this concern, these diseases are the focus of renewed scientific interest and much has been done in filariasis research in the past decade. This review summarizes the current status of filariasis, different control strategies, recent advances in antifilarial chemotherapy including currently used drugs, their pros and cons, their mechanism of action, and recently discovered targets and prototypes.
Keywords: Brugia malayi, filariasis control programs, loiasis, lymphatic filariasis, onchocerciasis, Onchocerca volvulus, target based antifilarial agents, Wuchereria bancrofti
Current Medicinal Chemistry
Title: Filariasis: Current Status, Treatment and Recent Advances in Drug Development
Volume: 18 Issue: 14
Author(s): D. Katiyar and L. K. Singh
Affiliation:
Keywords: Brugia malayi, filariasis control programs, loiasis, lymphatic filariasis, onchocerciasis, Onchocerca volvulus, target based antifilarial agents, Wuchereria bancrofti
Abstract: Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are diseases of tropical and subtropical countries causing considerable morbidity. The available control strategies have significant limitations such that current drugs are ineffective against macrofilariae (adult worms), require repeated and prolonged treatment over years and are threatened by emergence of drug resistance. Due to this concern, these diseases are the focus of renewed scientific interest and much has been done in filariasis research in the past decade. This review summarizes the current status of filariasis, different control strategies, recent advances in antifilarial chemotherapy including currently used drugs, their pros and cons, their mechanism of action, and recently discovered targets and prototypes.
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Cite this article as:
Katiyar D. and K. Singh L., Filariasis: Current Status, Treatment and Recent Advances in Drug Development, Current Medicinal Chemistry 2011; 18 (14) . https://dx.doi.org/10.2174/092986711795656234
DOI https://dx.doi.org/10.2174/092986711795656234 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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