Abstract
In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.
Keywords: Nanoparticles, magnetic materials, cell displacement, neuronal differentiation, anti-allodynia, antinociception, neuropathic pain, chronic pain, in vitro release, Franz diffusion cells, PLGA nanoparticles, amitriptyline, doxepin, imipramine, tricyclic antidepressants, Korsmeyer-Peppas
Current Nanoscience
Title: PC12 Interaction with Magnetic Nanotubes: Effects on Viability, Cell Differentiation and Cell Translocation Induced by a Magnetic Field
Volume: 7 Issue: 3
Author(s): Orazio Vittorio, Vittoria Raffa, Cristina Riggio, Andrea Pietrabissa and Alfred Cuschieri
Affiliation:
Keywords: Nanoparticles, magnetic materials, cell displacement, neuronal differentiation, anti-allodynia, antinociception, neuropathic pain, chronic pain, in vitro release, Franz diffusion cells, PLGA nanoparticles, amitriptyline, doxepin, imipramine, tricyclic antidepressants, Korsmeyer-Peppas
Abstract: In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.
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Cite this article as:
Vittorio Orazio, Raffa Vittoria, Riggio Cristina, Pietrabissa Andrea and Cuschieri Alfred, PC12 Interaction with Magnetic Nanotubes: Effects on Viability, Cell Differentiation and Cell Translocation Induced by a Magnetic Field, Current Nanoscience 2011; 7 (3) . https://dx.doi.org/10.2174/157341311795542499
DOI https://dx.doi.org/10.2174/157341311795542499 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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