Abstract
In addition to the currently available conventional therapeutic modalities i.e. chemotherapy, radiotherapy and surgery, there is a desperate need for more effective and less toxic therapies for head and neck malignancies. Chemotherapy alone shows high toxicity and a low survival rate. In some cases, malignant cells develop resistance to a particular drug and to combat this, a variety of approaches like intra-arterial therapy, induction chemotherapy, immunotherapy, photodynamic therapy as well as targeted molecular therapy have recently been employed. Techniques like intra-arterial and induction chemotherapy have showed some improvement in survival rate. Immununotherapy is in the experimental stages while photodynamic therapy is being clinically applied, but because of its side effects it is not very popular. Utilizing specific molecular targets with their inhibitors (like inhibitors of EGFR and VEGF); either alone or in combination with conventional therapy, may improve the survival rate of these patients. Blocking the signaling pathway (P13k/Akt/mTOR), with or without chemotherapy, may also overcome the problem of drug resistance. These modalities hold the promise of being more selective - harming fewer normal cells, reducing side effects and improving the quality of life. The various options and novel strategies currently available to the treating physician are critically examined in this review.
Keywords: Head immunotherapy, malignancy, molecular, neck, photodynamic, chemotherapy, Activated protein kinase, Cysteine-aspartic protease-9, Human papilloma virus, Kinesin spindle protein, Photodynamic therapy, Vascular Endothelial Growth Factor, Monoclonal antibodies
Current Cancer Drug Targets
Title: Novel Strategies in Therapy of Head and Neck Cancer
Volume: 11 Issue: 4
Author(s): R. Mehrotra, R. Ibrahim, A. Eckardt, O. Driemel and M. Singh
Affiliation:
Keywords: Head immunotherapy, malignancy, molecular, neck, photodynamic, chemotherapy, Activated protein kinase, Cysteine-aspartic protease-9, Human papilloma virus, Kinesin spindle protein, Photodynamic therapy, Vascular Endothelial Growth Factor, Monoclonal antibodies
Abstract: In addition to the currently available conventional therapeutic modalities i.e. chemotherapy, radiotherapy and surgery, there is a desperate need for more effective and less toxic therapies for head and neck malignancies. Chemotherapy alone shows high toxicity and a low survival rate. In some cases, malignant cells develop resistance to a particular drug and to combat this, a variety of approaches like intra-arterial therapy, induction chemotherapy, immunotherapy, photodynamic therapy as well as targeted molecular therapy have recently been employed. Techniques like intra-arterial and induction chemotherapy have showed some improvement in survival rate. Immununotherapy is in the experimental stages while photodynamic therapy is being clinically applied, but because of its side effects it is not very popular. Utilizing specific molecular targets with their inhibitors (like inhibitors of EGFR and VEGF); either alone or in combination with conventional therapy, may improve the survival rate of these patients. Blocking the signaling pathway (P13k/Akt/mTOR), with or without chemotherapy, may also overcome the problem of drug resistance. These modalities hold the promise of being more selective - harming fewer normal cells, reducing side effects and improving the quality of life. The various options and novel strategies currently available to the treating physician are critically examined in this review.
Export Options
About this article
Cite this article as:
Mehrotra R., Ibrahim R., Eckardt A., Driemel O. and Singh M., Novel Strategies in Therapy of Head and Neck Cancer, Current Cancer Drug Targets 2011; 11 (4) . https://dx.doi.org/10.2174/156800911795538039
DOI https://dx.doi.org/10.2174/156800911795538039 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
PDGF-D Signaling: A Novel Target in Cancer Therapy
Current Drug Targets Current State of Development of Genome Analysis in Livestock
Current Genomics Aromatherapy and the Central Nerve System (CNS): Therapeutic Mechanism and its Associated Genes
Current Drug Targets Approaching the Increasing Complexity of Non-small Cell Lung Cancer Taxonomy
Current Pharmaceutical Design Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy
Current Medicinal Chemistry Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules
Current Medicinal Chemistry In vivo Fluorescence Detection in Surgery: A Review of Principles, Methods, and Clinical Applications
Current Medical Imaging Targeting Signalling Cross-Talk between Cancer Cells and Cancer-Associated Fibroblast through Monocarboxylate Transporters in Head and Neck Cancer
Anti-Cancer Agents in Medicinal Chemistry Cyclin-Dependent Kinase-2 as a Target for Cancer Therapy: Progress in the Development of CDK2 Inhibitors as Anti-Cancer Agents
Current Medicinal Chemistry STAT3: A Molecular Target for Cancer Whose Time Has Come
Current Signal Transduction Therapy Design of Fucoidan Functionalized - Iron Oxide Nanoparticles for Biomedical Applications
Current Drug Delivery Development of Specific New ELISA for Bioanalysis of Cetuximab: A Monoclonal Antibody Used for Cancer Immunotherapy
Current Pharmaceutical Analysis Therapeutic Prospects for Parathyroid Hormone and Parathyroid Hormone Analogs
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Diagnostic Accuracy of Ultrasound for the Evaluation of Lateral Compartment Lymph Nodes in Papillary Thyroid Carcinoma
Current Medical Imaging Cancer Biomarker Discovery for Precision Medicine: New Progress
Current Medicinal Chemistry Oncorine, the World First Oncolytic Virus Medicine and its Update in China
Current Cancer Drug Targets Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine
Current Medicinal Chemistry Compounds from Wild Mushrooms with Antitumor Potential
Anti-Cancer Agents in Medicinal Chemistry Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis
Anti-Cancer Agents in Medicinal Chemistry Tumor-Associated Macrophages as Potential Targets for Anti-Cancer Activity of Marine Invertebrate-Derived Compounds
Current Pharmaceutical Design