Abstract
Better understanding of the effect of ageing on mitochondrial metabolism and of the mechanisms of action of various drugs is required to allow optimization of the treatment of many diseases with minimized risk of dangerous impairment of mitochondrial function. Numerous reports show that efficacy of medical treatment depends on the age of treated subjects. This applies particularly to the effect of drugs on various senescence-prone cellular pathways. In this review, we demonstrate how ageing affects various mitochondria-associated pathways and their response to a variety of factors. These factors include registered drugs and other chemicals, and account for diverse consequences which vary depending on the physiological condition. Pharmacological treatments aimed at improving mitochondrial function should thus have in mind the subject age.
Keywords: Mitochondria, ageing, drugs, toxic agents, respiratory chain, oxidative phosphorylation, oxidative stress, ROS, hispidin, antiretroviral therapy
Current Drug Targets
Title: Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease
Volume: 12 Issue: 6
Author(s): Jan Suski, Magdalena Lebiedzinska, Nuno G. Machado, Paulo J. Oliveira, Paolo Pinton, Jerzy Duszynski and Mariusz R. Wieckowski
Affiliation:
Keywords: Mitochondria, ageing, drugs, toxic agents, respiratory chain, oxidative phosphorylation, oxidative stress, ROS, hispidin, antiretroviral therapy
Abstract: Better understanding of the effect of ageing on mitochondrial metabolism and of the mechanisms of action of various drugs is required to allow optimization of the treatment of many diseases with minimized risk of dangerous impairment of mitochondrial function. Numerous reports show that efficacy of medical treatment depends on the age of treated subjects. This applies particularly to the effect of drugs on various senescence-prone cellular pathways. In this review, we demonstrate how ageing affects various mitochondria-associated pathways and their response to a variety of factors. These factors include registered drugs and other chemicals, and account for diverse consequences which vary depending on the physiological condition. Pharmacological treatments aimed at improving mitochondrial function should thus have in mind the subject age.
Export Options
About this article
Cite this article as:
Suski Jan, Lebiedzinska Magdalena, G. Machado Nuno, J. Oliveira Paulo, Pinton Paolo, Duszynski Jerzy and R. Wieckowski Mariusz, Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease, Current Drug Targets 2011; 12 (6) . https://dx.doi.org/10.2174/138945011795529029
DOI https://dx.doi.org/10.2174/138945011795529029 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biological Activities of Receptor-interacting Protein 140 in Adipocytes and Metabolic Diseases
Current Diabetes Reviews Fluoride Interactions: From Molecules to Disease
Current Signal Transduction Therapy Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome
Current Rheumatology Reviews Effect of a New Class of Compounds of the Group of Substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction
Current Vascular Pharmacology Epigenetic and Disease Targets by Polyphenols
Current Pharmaceutical Design Oxidative-Nitrosative Stress as a Contributing Factor to Cardiovascular Disease in Subjects with Diabetes
Current Vascular Pharmacology Metabolic Features of Alcoholic Liver Disease
Reviews on Recent Clinical Trials Simultaneous Spectrophotometric Determination of Iron (III) and Vanadium (V) in Water Samples Using a Combination of Partial Least Squares Regression and Solid Phase Extraction with Modified Octadecyl Silica Membrane Disks
Current Analytical Chemistry The Multiple Electrocardiographic Manifestations of Ventricular Repolarization Memory
Current Cardiology Reviews Pearls from the First Gulf Cardiac Amyloidosis Summit 2021
New Emirates Medical Journal Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy
Current Neurovascular Research The Role of the Chemokines in Myocardial Ischemia and Reperfusion
Current Vascular Pharmacology Targeting Calcium and the Mitochondria in Prevention of Pathology in the Heart
Current Drug Targets Potentiating the Naturally Occurring Process for Repair of Damaged Heart
Current Pharmaceutical Design Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives
Current Stem Cell Research & Therapy Current Biology of MTP: Implications for Selective Inhibition
Current Topics in Medicinal Chemistry Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease
Current Medicinal Chemistry L-Type Calcium Channels
Current Pharmaceutical Design Amiodarone - A ‘Broad Spectrum’ Antiarrhythmic Drug
Cardiovascular & Hematological Disorders-Drug Targets Eisenmenger Syndrome: Recent Advances in Pharmacotherapy
Cardiovascular & Hematological Agents in Medicinal Chemistry