Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease

Author(s): P. J. Higgins, M. Draper, M. Nelson

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 10 , Issue 2 , 2011

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Tetracyclines possess anti-inflammatory characteristics which are largely independent of their antibacterial activity. A variety of in vitro biologic effects have been reported for tetracyclines in both immune and non-immune cells. The in vivo therapeutic efficacy of tetracyclines in diseases such as rheumatoid arthritis, multiple sclerosis, and stroke has also been demonstrated in both animal models and clinical studies. This review describes the experimental evidence which demonstrates the various non-antibacterial anti-inflammatory activities of tetracyclines and discusses possible mechanisms of action of these drugs.

Keywords: Tetracycline, inflammation, autoimmunity, therapy, gastrointestinal symptoms, photosensitivity, tissue discoloration, allergic reaction, antibiotics, metalloproteases

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Article Details

Year: 2011
Page: [132 - 152]
Pages: 21
DOI: 10.2174/1871523011109020132
Price: $65

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PDF: 26