Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis

Author(s): Govardhan K. Shroff, Ramyasri Kuna, Kethora Dirsipam, Ravishekar Yalagala, Prasenjit Mitra

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 11 , Issue 3 , 2011

Become EABM
Become Reviewer


Altered cellular metabolism is a hallmark of tumorigenesis. Described first in 1924 by Otto Warburg, a cancer cell undergoes complete metabolic reprogramming to attain nutrient self-sufficiency for proliferation and survival. Interplay between diverse signalling cascades confers this metabolic advantage. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor.

Keywords: Warburg effect, glutaminolysis, aerobic glycolysis, Myc, Akt, mTOR, Hexokinase II, SGLT2 expression, mitochondrial outer membrane, isozymes, Fibroblast growth factor receptor (FGFR), Pyruvate kinase, tumor cell populations, hypoxic tumor cells

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [272 - 279]
Pages: 8
DOI: 10.2174/187152011795347531
Price: $65

Article Metrics

PDF: 12