Peptide-Based Subunit Nanovaccines

Author(s): Mariusz Skwarczynski, Istvan Toth

Journal Name: Current Drug Delivery

Volume 8 , Issue 3 , 2011

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Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials.

Keywords: Subunit vaccine, peptide epitope, nanotechnology, nanoparticles, infectious diseases, Nanovaccine, autoimmunity, lipid carriers, inorganic materials, pathogens

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Article Details

Year: 2011
Page: [282 - 289]
Pages: 8
DOI: 10.2174/156720111795256192
Price: $65

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PDF: 31