Triple Threat: The Na+/Ca2+ Exchanger in the Pathophysiology of Cardiac Arrhythmia, Ischemia and Heart Failure

Author(s): Christian Pott, Lars Eckardt, Joshua I. Goldhaber

Journal Name: Current Drug Targets

Volume 12 , Issue 5 , 2011

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The Na+/Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism of the cardiac myocyte and thus is crucial for maintaining Ca2+ homeostasis. It is involved in the regulation of several parameters of cardiac excitation contraction coupling, such as cytosolic Ca2+ concentration, repolarization and contractility. Increased NCX activity has been identified as a mechanism promoting heart failure, cardiac ischemia and arrhythmia. Transgenic mice as well as pharmacological interventions have been used to support the idea of using NCX inhibition as a future pharmacological strategy to treat cardiovascular disease.

Keywords: Na+/Ca2+ exchanger, arrhythmia, ischemia, heart failure, transgenic mice, Ca2+ handling, NCX, genetic knockout, hypertension, cardiovascular disease

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Article Details

Year: 2011
Page: [737 - 747]
Pages: 11
DOI: 10.2174/138945011795378559
Price: $65

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