Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

Author(s): Prakash T. Parvatkar, Perunninakulath S. Parameswaran, Santosh G. Tilve

Journal Name: Current Organic Chemistry

Volume 15 , Issue 7 , 2011

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The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub Cryptolepis sanguinolenta and are important due to their wide spectrum of biological properties. This review describes the isolation, brief biological activities and various synthetic methodologies developed during recent years for the preparation of this important class of alkaloids, with special emphasis on preparation and properties of cryptolepine 1, isocryptolepine 2 and neocryptolepine 3.

Keywords: Alkaloid, cryptolepine, heteroaromatic, indoloquinoline, isocryptolepine, neocryptolepine, tuberculosis, AIDS, Ghana-strain, spectroscopy, Palladium-catalyzed Coupling Reaction, regioselective coupling reaction, Suzuki arylation, Myers method, Aza-Wittig Reaction

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Article Details

Year: 2011
Page: [1036 - 1057]
Pages: 22
DOI: 10.2174/138527211794785118
Price: $58

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