Characterizing the Surface Chemistry of Nanoparticles: An Analogy to Solid-Phase Synthesis Samples

Author(s): Yin Liu, Bing Yan

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 14 , Issue 3 , 2011

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Chemical modifications of nanoparticles (NPs) surfaces can be used to regulate their activities, remove their toxic effects, and enable them to perform desired functions. Similar to SPS samples, modified NPs also have smallmolecules on the surface of a solid support. The need to monitor synthesis, optimize reaction conditions, and characterize the products is quite similar in both situations. FTIR, NMR, MS and other analytical methods have been used as effective methods to analyze surface bound molecules and monitor organic reactions directly, or indirectly, on a solid phase of a resin or a NPs.

Keywords: Nanoparticles, solid-phase synthesis, FTIR, NMR, MS, X-ray photoelectron spectroscopy, elemental analysis, Infrared spectroscopy, oxidation, combinatorial chemistry, quantitative analysis

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Article Details

Year: 2011
Page: [191 - 197]
Pages: 7
DOI: 10.2174/138620711794728798
Price: $65

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