Sequence Recognition of DNA by Lexitropsins

Author(s): David S. Goodsell

Journal Name: Current Medicinal Chemistry

Volume 8 , Issue 5 , 2001

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Abstract:

Lexitropsins are modular polyamide molecules that are designed to “read” the base sequence of DNA. Lexitropsins constructed of three types of subunits-- pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2001
Page: [509 - 516]
Pages: 8
DOI: 10.2174/0929867003373319
Price: $65

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