Abstract
The specific actions of capsaicin on the small primary afferent neurons with regard to neurogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are referred, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by a recent literature survey. TRPV1- expressing nerve fibers were recently reported to be responsible for the itching sensation. Three possible itching pathways were raised. The participation of pure sensory nerve fibers which exclusively transmit itchiness has not been found, as yet.
Keywords: Capsaicin, histamine, itch, neurogenic inflammation, plasma extravasation, TRPV1, Axon reflex, Antidromic vasodilation, C- fibers, Inorganic polycationic dye
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons
Volume: 10 Issue: 1
Author(s): Akio Hiura and Hiroshi Nakagawa
Affiliation:
Keywords: Capsaicin, histamine, itch, neurogenic inflammation, plasma extravasation, TRPV1, Axon reflex, Antidromic vasodilation, C- fibers, Inorganic polycationic dye
Abstract: The specific actions of capsaicin on the small primary afferent neurons with regard to neurogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are referred, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by a recent literature survey. TRPV1- expressing nerve fibers were recently reported to be responsible for the itching sensation. Three possible itching pathways were raised. The participation of pure sensory nerve fibers which exclusively transmit itchiness has not been found, as yet.
Export Options
About this article
Cite this article as:
Hiura Akio and Nakagawa Hiroshi, An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (1) . https://dx.doi.org/10.2174/187152311795325505
DOI https://dx.doi.org/10.2174/187152311795325505 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications
Current Medicinal Chemistry The Molecular Genetics of Migraine: Toward the Identification of Responsible Genes
Current Genomics Ocular Application of Macrobiomolecules in Anti-Allergy and Anti- Inflammation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Acute Respiratory Failure in Obstetric Patients
Current Women`s Health Reviews Clinical and Pre-clinical Applications of the Transcendental Meditation Program® in the Prevention and Treatment of Essential Hypertension and Cardiovascular Disease in Youth and Adults
Current Hypertension Reviews Abnormal Insulin Signaling: Early Detection of Silent Coronary Artery Disease-Erectile Dysfunction?
Current Pharmaceutical Design Metabolic and Cardiovascular Ageing Indices in Relation to Glycated Haemoglobin in Healthy and Diabetic Subjects
Current Aging Science Novel Anti-Platelets in Stable Coronary Artery Disease
Current Pharmaceutical Design Relevance of Postprandial Lipemia in Metabolic Syndrome
Current Vascular Pharmacology Biomarkers Determining Cardiovascular Risk in Patients with Kidney Disease
Current Medicinal Chemistry The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis
Current Medicinal Chemistry Hybrid Stress Testing by Adenosine Infusion and Exercise Myocardial Perfusion Imaging: A Critical Appraisal
Current Cardiology Reviews Human Anthrax as a Re-Emerging Disease
Recent Patents on Anti-Infective Drug Discovery Can Imaging Techniques Identify Smoking-Related Cardiovascular Disease?
Current Pharmaceutical Design VEGF, a Mediator of the Effect of Experience on Hippocampal Neurogenesis
Current Alzheimer Research The Fixed Combination Efficacy Assessment in Patients with Secondary Neovascular Glaucoma and Diabetes Mellitus
Current Diabetes Reviews Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety Neurovascular Changes in Acute, sub-Acute and Chronic Mouse Models of Parkinson’s Disease
Current Neurovascular Research Endothelial Dysfunction, Obesity and Insulin Resistance
Current Vascular Pharmacology Endothelial Function: A Surrogate Endpoint in Cardiovascular Studies?
Current Pharmaceutical Design