Abstract
This review describes the clinical application of β-adrenergic blocking drugs over time in patients with congestive heart failure. The different pharmacological properties of these drugs in relation to clinical outcomes raise questions as to their optimal desirable profile based on studies showing the undesirable effects of excessive β2-AR activation. The rationale for the use of selective β2-AR antagonists in heart failure is discussed.
Keywords: Selective adrenoceptor blockade, heart failure, MAP/ERK activation
Current Pharmaceutical Design
Title: Evolving Concepts Concerning Cardiac β-Adrenoceptor Function in Heart Failure
Volume: 16 Issue: 37
Author(s): J. Black and D. Fitzgerald
Affiliation:
Keywords: Selective adrenoceptor blockade, heart failure, MAP/ERK activation
Abstract: This review describes the clinical application of β-adrenergic blocking drugs over time in patients with congestive heart failure. The different pharmacological properties of these drugs in relation to clinical outcomes raise questions as to their optimal desirable profile based on studies showing the undesirable effects of excessive β2-AR activation. The rationale for the use of selective β2-AR antagonists in heart failure is discussed.
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Cite this article as:
Black J. and Fitzgerald D., Evolving Concepts Concerning Cardiac β-Adrenoceptor Function in Heart Failure, Current Pharmaceutical Design 2010; 16 (37) . https://dx.doi.org/10.2174/138161210794519200
DOI https://dx.doi.org/10.2174/138161210794519200 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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