In recent years, nanomaterial science and supramolecular chemistry have experienced rapid development and attracted the interests of scientists from many diverse fields. Novel features have frequently served as paradigms for the study of the evolution of structural recombination between cation and anion ions by the means of molecule-ion interactions between inorganic ions and organic additives such as cyclodextrins (CDs). Actually, the presence of CDs as well as other additives has a significant influence on the size and morphology of inorganic nanoparticles (INPs) during the formation processes of INPs. However, why and how does the existence of CDs affect the growth of INPs? There was little information reported in available literatures. Accordingly, this current work attempts to elucidate the role of CDs and their derivatives in regulation of the formation of INPs and to compare with the effects of some surfactants, other amylases and polymers. Our motivation is to formulate a simple relationship that will provide an insight into some of the strategies developed to improve the crystalline phase, surface area, particle size and morphology of INPs.