Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs

Author(s): Ya-Jun Wang, Yu-Guo Zheng, Ya-Ping Xue, Yuan-Shan Wang, Yin-Chu Shen

Journal Name: Current Pharmaceutical Analysis

Volume 7 , Issue 1 , 2011

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Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.

Keywords: Diabetes, Acarbose, Analysis, Liquid chromatography, Capillary electrophoresis, Biosensor, α-glucosidase Inhibitor, Non-Insulin-Dependent Diabetes Mellitus (NIDDM), Refractive Index Detection (RID), Evaporative Light Scattering Detection (ELSD), Normal Phase Liquid Chromatography (NPLC)

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Article Details

Year: 2011
Published on: 01 March, 2012
Page: [12 - 20]
Pages: 9
DOI: 10.2174/157341211794708721

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PDF: 43