Buccoadhesive Dosage Form Containing Antifungal Agent for Treating Oropharyngeal Candidiasis: A Review

Author(s): Mohamed S. Pendekal, Muzzammil Shariff, Pramod K. Tegginamat

Journal Name: Current Drug Therapy

Volume 6 , Issue 1 , 2011


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Abstract:

Oral candidiasis is a common fungal infection in patients with an impaired immune system, such as those undergoing chemotherapy for cancer and patients with AIDS (Acquired immune deficiency syndrome). The majority of infections are due to Candida albicans although other species such as Candida glabrata, Candida tropicalis, Candida krusei and Candida parapsilosis are increasingly isolated. The objective of this article is to review candidiasis, types of candidiasis, discussing the structure and environment and permeability of the oral mucosa. Buccoadhesive drug delivery will also be reviewed with an emphasis on Bioadhesion, theories of Bioadhesion, investigated mucoadhesive polymers and Buccoadhesive tablet/film containing antifungal agent for treating oropharyngeal candidiasis.

Keywords: AIDS, buccoadhesive, cancer, candida species, mucosa, oral candidiasis, infection, mouth care regimen, immunocompromised, fungus, Oropharyngeal, candidiasis, Human immunodeficiency virus, drug delivery, nasal, rectal, vaginal, ocular, oral cavity, enzymatic flora, drug absorption, fungi, Candida glabrata, antifungal drugs, leukemia, neoplasia, steroid, prophylaxis, neutropenia, sarcoma, Plaques, necrotic material, stratum corneum, Candida microorganisms, cytotoxic chemotherapy, cell mediated immunity, dysphagia, axillae, vaginal infection, Candida, pregnancy, estrogen content, Candidemia, hepatosplenic candidiasis, bloodstream, squamous epithelium, glucosyl ceramides, permeability, epithelial cells, SALIVA, sub maxillary, Bioadhesion, iffusion, electronic, fracture, non-covalent, wetting theory, Hydration, Cross-Linking Density, Concentration, Molecular Weight, Hydrogen Bonding Capacity, Charge, Environmental Factors, multidirectional drug release, semisolids, ointments, captopril, oral dose, polymer(s)

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2011
Published on: 01 March, 2012
Page: [55 - 64]
Pages: 10
DOI: 10.2174/157488511794078997

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