Abstract
Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important antiinflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. Glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each others activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.
Keywords: Glucocorticoids, steroids, breast cancer, review, circadian, paracrine, glucocorticoid receptor, treatment, homeostasis, asthma, arthritis, autoimmune diseases, chemotherapy, leukemia, lymphoma, CNS, Oestrogen, progesterone, nuclear factor-B, Dexomethasone, sulfotransferase, rheumatoid arthritis, metabolic syndrome, NSAID, MCF10A-Myc mammary carcinoma cells, RU486, SGK-1, Serum and glucocorticoid induced Kinase 1, MAP kinase phosphatase-1, Trastuzumab-induced cell growth, CIRCADIAN RHYTHMS, Estrogen receptors, Human Epidermal Growth Factor Receptor-2, Endocrine Therapy
Current Pharmaceutical Design
Title: Role of Glucocorticoids in Breast Cancer
Volume: 16 Issue: 32
Author(s): Jayant S. Vaidya, Gustavo Baldassarre, Mangesh A. Thorat and Samuele Massarut
Affiliation:
Keywords: Glucocorticoids, steroids, breast cancer, review, circadian, paracrine, glucocorticoid receptor, treatment, homeostasis, asthma, arthritis, autoimmune diseases, chemotherapy, leukemia, lymphoma, CNS, Oestrogen, progesterone, nuclear factor-B, Dexomethasone, sulfotransferase, rheumatoid arthritis, metabolic syndrome, NSAID, MCF10A-Myc mammary carcinoma cells, RU486, SGK-1, Serum and glucocorticoid induced Kinase 1, MAP kinase phosphatase-1, Trastuzumab-induced cell growth, CIRCADIAN RHYTHMS, Estrogen receptors, Human Epidermal Growth Factor Receptor-2, Endocrine Therapy
Abstract: Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important antiinflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. Glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each others activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.
Export Options
About this article
Cite this article as:
S. Vaidya Jayant, Baldassarre Gustavo, A. Thorat Mangesh and Massarut Samuele, Role of Glucocorticoids in Breast Cancer, Current Pharmaceutical Design 2010; 16 (32) . https://dx.doi.org/10.2174/138161210793797906
DOI https://dx.doi.org/10.2174/138161210793797906 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Current Organic Synthesis Cancer Molecular Imaging: Radionuclide-Based Biomarkers of the Epidermal Growth Factor Receptor (EGFR)
Current Topics in Medicinal Chemistry Antitumor Carbazoles
Anti-Cancer Agents in Medicinal Chemistry Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II)
Anti-Cancer Agents in Medicinal Chemistry PPARγ-targeting Potential for Radioprotection
Current Drug Targets Preparation and Characterization of Chitosan Monomer/Organic Rectorite Nanocomposite
Current Nanoscience The Tachykinergic System as Avenues for Drug Intervention
Recent Patents on CNS Drug Discovery (Discontinued) Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Topics in Medicinal Chemistry AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease
Current Alzheimer Research Potential Minor Haplotypes of CYP2D6 in the Japanese Population
Drug Metabolism Letters Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance
Anti-Cancer Agents in Medicinal Chemistry Peptide Based Vaccine Design for Cancer Immunotherapy
Letters in Drug Design & Discovery Recent Patents Review in Three Dimensional Ultrasound Imaging
Recent Patents on Biomedical Engineering (Discontinued) The Therapeutic Potential of miR-7 in Cancers
Mini-Reviews in Medicinal Chemistry Coumarin and Isocoumarin as Serine Protease Inhibitors
Current Pharmaceutical Design Breast Cancer: Current Molecular Therapeutic Targets and New Players
Anti-Cancer Agents in Medicinal Chemistry Editorials (Pharmacogenomics in Primary Care: A Crucial Entry Point for Global Personalized Medicine?)
Current Pharmacogenomics and Personalized Medicine TWIST1 Gene: First Insights in Felis catus
Current Genomics Latest Advances in Breast Sonography
Recent Patents on Medical Imaging GPR40 Carboxylic Acid Receptor Family and Diabetes: A New Drug Target
Current Drug Targets