Screening of Enzyme Inhibitors from Traditional Chinese Medicine

Author(s): Yao Shen, Yuming Hu, Bo Chen, Shouzhuo Yao

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 10 , 2010

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Abstract:

Traditional Chinese medicine (TCM) has been used for more than 4000 years. By comparison with large combinatorial chemistry libraries and natural products of the West for high-throughput screening (HTS) of new drugs discovery, an advantage of TCM is that the preparation has clear efficacies on the therapy of some diseases. Although the effective components are not clear, the clear efficacies of TCM have been identified for long time practice, Therefore, TCMs should be valuable lead compound libraries with a definite therapy efficacy from the viewpoint of HTS. Nevertheless, current HTS technologies are not easily adapted to investigate TCMs because they are designed for screening a relatively pure known chemical at a known concentration. In contrast, TCMs are mixtures of unknown compounds in unknown concentrations that may differ markedly between samples from different plants. This article reviews the current and future researches on the enzyme inhibitors screening from TCM.

Keywords: Affinity adsorption, capillary electrophoresis, Chinese medicinal materials, enzyme inhibitor, frontal chromatography, high-throughput screening, micro-reactor, traditional Chinese patent medicines, leaf flavonoids extract, hawthorn, HLFE, C-glycosylflavones, vitexin, isovitexin, orientin, isooriention, acetylcholinesterase, AChE, arsenic trioxide, ginseng saponin, epoxide hydrolase, Sophora flavescens, Anticholinesterases, Cyrtomium confertifolium, Onychium japonicum, Woodwardia japonica, Pteris vittata, Angiotensin I-converting enzyme, Qing-Kai-Ling, middle cerebral artery occlusion, tumor necrosis factor converting enzyme, cytochrome P450, electrophoretically mediated micro analytical, hexadimethrine bromide, Inject-Mix-React-Separate-and-Quantitate, transverse diffusion of laminar flow profiles, methoxyresorufin-O-demethylation, renin-angiotensin-aldosterone system

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2010
Page: [885 - 899]
Pages: 15
DOI: 10.2174/138620710793360239
Price: $65

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