Mn-SOD and Chronic Inflammation of Gastric Mucosa

Author(s): J. Dovhanj, D. Svagelj, M. Smolic, R. Smolic, I. Maric

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 9 , Issue 4 , 2010

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The involvement of reactive oxygen species in the inflammatory tissue destruction is well known. Significant changes in the activity and expression of several isoforms of superoxide dismutase were observed in the human gastric disease. Mn-SOD attracted the attention of researchers because of its inducibility by oxidative stress. There is increasing evidence that oxidative stress plays a role in the progression of mucosal damage leading to gastric cancer. The evaluation of possible modulation of Mn-SOD activity during chronic inflammation of gastric mucosa could reveal whether its assessment is important to prevent the accumulation of gastric epithelial cell damage and thereby reduce the risk of gastric carcinoma.

Keywords: Free radical, gastric mucosa, inflammation, oxidative stress, ROS, SOD.

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Article Details

Year: 2010
Page: [347 - 354]
Pages: 8
DOI: 10.2174/1871523011009040347
Price: $65

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