Alpha-1 Antitrypsin: It’s Role in Health and Disease

Author(s): Mohammad Hashemi, Pawan Sharma, Mehdi Eshraghi, Mohammad Naderi, Abdolkarim Moazeni-Roodi, Hamid Mehrabifar, Mohsen Taheri

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 9 , Issue 4 , 2010

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Alpha-1 Antitrypsin (AAT) is a 52 kDa glycoprotein that is principally synthesized by the liver. It is the archetype of the serine protease inhibitor (Serpin) superfamily of proteins, which has a major role in inactivating neutrophil elastase and other proteases to retain protease–antiprotease equilibrium. AAT deficiency is a rare monogenic disorder characterized by low levels of AAT in serum and the lungs and it is well known to be associated with emphysema and liver disease. Inadequate knowledge of AAT deficiency might be due to under-recognition of this protein. To date, the exact role of AAT deficiency in various diseases has not been extensively elucidated. In this review, the current knowledge regarding the role AAT in various disorders will be discussed.

Keywords: Alpha 1-antitrypsin, serine protease inhibitors, SERPIN.

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [279 - 288]
Pages: 10
DOI: 10.2174/1871523011009040279
Price: $65

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