Abstract
Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in immune/inflammatory disorders. Well-designed animal studies have shown its critical role in experimental allergic inflammation and human in vitro studies have consistently demonstrated its up-regulation in several conditions such as asthma and rheumatoid arthritis. The ligand for IL1RL1 is IL33 which emerged as playing an important role in initiating eosinophilic inflammation and activating other immune cells resulting in an allergic phenotype. An IL1RL1 single nucleotide polymorphism (SNP) was among the most significant results of a genome-wide scan investigating eosinophil counts; in the same study, this SNP associated with asthma in 10 populations. The IL1RL1 gene resides in a region of high linkage disequilibrium containing interleukin 1 receptor genes as well as interleukin 18 receptor and accessory genes. This poses a challenge to researchers interested in deciphering genetic association signals in the region as all of the genes represent interesting candidates for asthma and allergic disease. The IL1RL1 gene and its resulting soluble and receptor proteins have emerged as key regulators of the inflammatory process implicated in a large variety of human pathologies We review the function and expression of the IL1RL1 gene. We also describe the role of IL1RL1 in asthma, allergy, cardiovascular disease, infections, liver disease and kidney disease.
Keywords: Asthma, genetics, IL1RL1, immunity, inflammation, respiratory, Interleukin 1 receptor-like 1, single nucleotide polymorphism, SNP, ST2, DER4, FIT-1, interleukin 1 super- family, linkage disequilibrium, heterodimeric IL18 receptor, proximal promoter, distal promoter, aka ST2L, aka sST2, aka vST2, Th2 cells, Nippostrongylus brasiliensis, Mitogen-Activated Protein kinases ERK1, ERK2, Chronic Obstructive Pulmonary Disease, electrocardiogram, Presage, Toxoplasma gondii, alanine aminotransferase
Current Genomics
Title: Genetics of Interleukin 1 Receptor-Like 1 in Immune and Inflammatory Diseases
Volume: 11 Issue: 8
Author(s): Loubna Akhabir and Andrew Sandford
Affiliation:
Keywords: Asthma, genetics, IL1RL1, immunity, inflammation, respiratory, Interleukin 1 receptor-like 1, single nucleotide polymorphism, SNP, ST2, DER4, FIT-1, interleukin 1 super- family, linkage disequilibrium, heterodimeric IL18 receptor, proximal promoter, distal promoter, aka ST2L, aka sST2, aka vST2, Th2 cells, Nippostrongylus brasiliensis, Mitogen-Activated Protein kinases ERK1, ERK2, Chronic Obstructive Pulmonary Disease, electrocardiogram, Presage, Toxoplasma gondii, alanine aminotransferase
Abstract: Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in immune/inflammatory disorders. Well-designed animal studies have shown its critical role in experimental allergic inflammation and human in vitro studies have consistently demonstrated its up-regulation in several conditions such as asthma and rheumatoid arthritis. The ligand for IL1RL1 is IL33 which emerged as playing an important role in initiating eosinophilic inflammation and activating other immune cells resulting in an allergic phenotype. An IL1RL1 single nucleotide polymorphism (SNP) was among the most significant results of a genome-wide scan investigating eosinophil counts; in the same study, this SNP associated with asthma in 10 populations. The IL1RL1 gene resides in a region of high linkage disequilibrium containing interleukin 1 receptor genes as well as interleukin 18 receptor and accessory genes. This poses a challenge to researchers interested in deciphering genetic association signals in the region as all of the genes represent interesting candidates for asthma and allergic disease. The IL1RL1 gene and its resulting soluble and receptor proteins have emerged as key regulators of the inflammatory process implicated in a large variety of human pathologies We review the function and expression of the IL1RL1 gene. We also describe the role of IL1RL1 in asthma, allergy, cardiovascular disease, infections, liver disease and kidney disease.
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Cite this article as:
Akhabir Loubna and Sandford Andrew, Genetics of Interleukin 1 Receptor-Like 1 in Immune and Inflammatory Diseases, Current Genomics 2010; 11 (8) . https://dx.doi.org/10.2174/138920210793360907
DOI https://dx.doi.org/10.2174/138920210793360907 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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