Evaluation of Assam Bora Rice Starch as Plasma Volume Expander by Polymer Analysis

Author(s): Ashokanshu Bhattacharya, Sohail Akhter, Sheikh Shahnawaz, Abdul Wadood Siddiqui, Mohammad Zaki Ahmad

Journal Name: Current Drug Delivery

Volume 7 , Issue 5 , 2010

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Water soluble polysaccharides are currently finding increasing use as a basis material for plasma volume expander. In clinical setting it is desirable to have a precise knowledge of steric and chemical structure, since these affect the pharmacokinetics and pharmacology of plasma volume expander. Branch component of starch amylopectin is very similar in structure to glycogen, the reserve polysaccharide of animal and therefore is liable to be compatible with body tissue. The knowledge of weight average molecular mass, degree of branching, osmotic pressure and coil dimension are essential, since low molecular mass do not have desirable effect and large molar mass have undesirable effect. Assam Bora rice starch was characterized by polymer analysis for use as plasma volume expander. Characterization involves the determination of FTIR spectra, degree of branching by H1 NMR, osmotic pressure by internal measurement technique, establishment of Mark-Houwink relationship and determination of Molecular weight – viscosity relationship.

Keywords: Plasma volume expander, assam bora rice, NMR, degree of branching, osmotic pressure

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Article Details

Year: 2010
Page: [436 - 441]
Pages: 6
DOI: 10.2174/156720110793566209
Price: $65

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