Synthesis of Functionalized Chromenes from Meldrum’s Acid, 4- Hydroxycoumarin, and Ketones or Aldehydes

Author(s): Maryam Sabbaghan, Issa Yavari, Zinatossadat Hossaini

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 9 , 2010


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Abstract:

An efficient synthesis of 4-alkyl-4-methyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-dione or 4-aryl-3,4- dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones via reaction 4-hydroxycoumarin with Meldrum’s acid and ketones or aldehydes is described.

Keywords: Chromene, proline, aqueous media, meldrum’s acid, 4-hydroxycoumarin

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Article Details

VOLUME: 13
ISSUE: 9
Year: 2010
Page: [813 - 817]
Pages: 5
DOI: 10.2174/138620710792927358
Price: $65

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