Abstract
Hepatitis B virus (HBV) infected hepatitis is the common infectious disease. In the World Conservative Estimate Plan, the number of persons chronically infected with HBV is more than 300 million. Current regimen of treatment is far from satisfactory, as it is associated with certain side effects and viral resistance capacity. Therefore, a serious attention has recently been paid to the design and development of new potent anti-HBV agents. A variety of drugs have been synthesized and screened for their anti-HBV effects. These include nucleosides, natural compounds, quinolines, benzodiazepines, indoles, etc. Many of them are in wide trend in current treatment regimen. In this review, we have presented the recent development on the design and development of all categories of HBV inhibitors studied.
Keywords: Anti-hepatitis B virus agents, nucleosides, quinolines, benzodiazepines, indoles, Anti-Hepatitis B, Virus, (HBV), STERIMOL parameter, surface antigen, nucleocapsid core antigen, pre-core antigen, HBV replication, DNA polymerase, DNA, RNA, Chronic Hepatitis, Active prophylaxis, Passive Immunization, Interferon, Immunomodulators, Adoptive Immune Transfer, Nucleoside Analogs, thrombocytopenia, anemia, DHBV, famciclovir, Sophora flavescens, X-ray analysis, Hypserpa nitida, Alisma orientalis, replication, Inhi-bition assay, BENZODIAZEPINESINDOL, lamivudine, (QSAR)
Current Medicinal Chemistry
Title: Design and Development of Anti-Hepatitis B Virus Agents
Volume: 17 Issue: 29
Author(s): S. Kaushik, S. P. Gupta and P. K. Sharma
Affiliation:
Keywords: Anti-hepatitis B virus agents, nucleosides, quinolines, benzodiazepines, indoles, Anti-Hepatitis B, Virus, (HBV), STERIMOL parameter, surface antigen, nucleocapsid core antigen, pre-core antigen, HBV replication, DNA polymerase, DNA, RNA, Chronic Hepatitis, Active prophylaxis, Passive Immunization, Interferon, Immunomodulators, Adoptive Immune Transfer, Nucleoside Analogs, thrombocytopenia, anemia, DHBV, famciclovir, Sophora flavescens, X-ray analysis, Hypserpa nitida, Alisma orientalis, replication, Inhi-bition assay, BENZODIAZEPINESINDOL, lamivudine, (QSAR)
Abstract: Hepatitis B virus (HBV) infected hepatitis is the common infectious disease. In the World Conservative Estimate Plan, the number of persons chronically infected with HBV is more than 300 million. Current regimen of treatment is far from satisfactory, as it is associated with certain side effects and viral resistance capacity. Therefore, a serious attention has recently been paid to the design and development of new potent anti-HBV agents. A variety of drugs have been synthesized and screened for their anti-HBV effects. These include nucleosides, natural compounds, quinolines, benzodiazepines, indoles, etc. Many of them are in wide trend in current treatment regimen. In this review, we have presented the recent development on the design and development of all categories of HBV inhibitors studied.
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Cite this article as:
Kaushik S., P. Gupta S. and K. Sharma P., Design and Development of Anti-Hepatitis B Virus Agents, Current Medicinal Chemistry 2010; 17 (29) . https://dx.doi.org/10.2174/092986710793176375
DOI https://dx.doi.org/10.2174/092986710793176375 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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