Abstract
Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemotherapeutic agents currently used in the clinic. These same features represent potentially targetable “states” that are essentially tumor specific. The assessment of the chromosomal state of a cancer cell population may provide a guide for the selection or development of drugs active against aggressive and intractable cancers.
Keywords: Aneuploidy, Chromosomal instability, Cancer, Anticancer drugs, NCI-60, Karyotic abnormalities, CIN, Chromosomal instability phenotype, Heterogeneity, Cancer progression, Chemotherpeutic agents, Anticancer therapy, Drosophila, Trisomies, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neoplasia, Tumorigenesis, Microsatellite instability, CENP-E heterozygous, Chromatid cohesion, Centrosomes, Kinetochore, Chromosome missegregating, JAK-STAT signaling pathways, ECM-receptor interaction pathways, Griseofulvin, Cancer spectrum, GI50 data vectors, Anthracyclines, Antifolates, Alkylators, Topoisomerase agents, Gemcitabine, 5-fluorouracil, Mercapto-3H quinazolines
Current Drug Targets
Title: Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells
Volume: 11 Issue: 10
Author(s): Anna V. Roschke and Ilan R. Kirsch
Affiliation:
Keywords: Aneuploidy, Chromosomal instability, Cancer, Anticancer drugs, NCI-60, Karyotic abnormalities, CIN, Chromosomal instability phenotype, Heterogeneity, Cancer progression, Chemotherpeutic agents, Anticancer therapy, Drosophila, Trisomies, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neoplasia, Tumorigenesis, Microsatellite instability, CENP-E heterozygous, Chromatid cohesion, Centrosomes, Kinetochore, Chromosome missegregating, JAK-STAT signaling pathways, ECM-receptor interaction pathways, Griseofulvin, Cancer spectrum, GI50 data vectors, Anthracyclines, Antifolates, Alkylators, Topoisomerase agents, Gemcitabine, 5-fluorouracil, Mercapto-3H quinazolines
Abstract: Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemotherapeutic agents currently used in the clinic. These same features represent potentially targetable “states” that are essentially tumor specific. The assessment of the chromosomal state of a cancer cell population may provide a guide for the selection or development of drugs active against aggressive and intractable cancers.
Export Options
About this article
Cite this article as:
V. Roschke Anna and R. Kirsch Ilan, Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells, Current Drug Targets 2010; 11 (10) . https://dx.doi.org/10.2174/1389450111007011341
DOI https://dx.doi.org/10.2174/1389450111007011341 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Aminophosphonic Acids of Potential Medical Importance
Current Medicinal Chemistry - Anti-Cancer Agents Combining Cytotoxic and Immune-Mediated Gene Therapy to Treat Brain Tumors
Current Topics in Medicinal Chemistry CypA: A Potential Target of Tumor Radiotherapy and/or Chemotherapy
Current Medicinal Chemistry Evaluation of <sup>177</sup>Lu-EDTMP in Dogs with Spontaneous Tumor Involving Bone: Pharmacokinetics, Dosimetry and Therapeutic Efficacy
Current Radiopharmaceuticals Cancer T Cell Immunotherapy with Bispecific Antibodies and Chimeric Antigen Receptors
Recent Patents on Anti-Cancer Drug Discovery MicroRNAs and Peroxisome Proliferator-Activated Receptors Governing the Differentiation of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy RGD Peptide–mediated Molecular Imaging for Targeting Integrin Alpha(v) Beta(3) in Tumors: A Review
Current Medical Imaging Effects of Drug Transporters on Pharmacological Responses and Safety
Current Drug Metabolism Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
Clinical Cancer Drugs Nanofibers: New Insights for Drug Delivery and Tissue Engineering
Current Topics in Medicinal Chemistry Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies
Current Cancer Drug Targets Micro/Nanoparticle Design and Fabrication for Pharmaceutical Drug Preparation and Delivery Applications
Current Drug Therapy Anti-cancer Scopes and Associated Mechanisms of Scutellaria Extract and Flavonoid Wogonin
Current Cancer Therapy Reviews MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review
Current Cancer Drug Targets The Impact of Omega-3 Fatty Acids on Osteoporosis
Current Pharmaceutical Design Radionuclides Used in Nuclear Medicine Therapy – From Production to Dosimetry
Current Medical Imaging The Role of Connexins in Carcinogenesis: Review of Current Knowledge
Current Signal Transduction Therapy Therapeutic Use of MicroRNAs in Cancer
Anti-Cancer Agents in Medicinal Chemistry Protein Targeting Constructs in Alpha Therapy
Current Radiopharmaceuticals Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine
CNS & Neurological Disorders - Drug Targets