Update on MDS Therapy: From Famine to Feast

Author(s): Preeti Chaudhary, Chirag Shah

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 8 , Issue 4 , 2010

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Myelodysplastic syndromes (MDS) are acquired hematopoietic stem cell disorders characterized by ineffective hematopoiesis, cellular dysfunction and increased risks of transformation into acute myeloid leukemia.The natural history of the disease remains variable and depends upon multiple prognostic factors at the time of initial diagnosis. The current prognostic models are helpful to determine the outcome of individual patients but they remain imperfect. Earlier, the most frequent treatment given for patients with MDS was supportive with transfusion of blood products and administration of erythropoietic stimulating agents and iron chelation therapy. Now, there is an arsenal of therapies available and the landscape for the treatment of MDS is rapidly evolving. There are several FDA approved therapies available for this disorder that makes this review particularly timely and relevant.

Keywords: Myelodysplastic syndrome, best supportive care, erythropoietin stem cell transplant, 5-azacitidine, decatibine, immunosuppressive therapy, lenalidomide.

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [187 - 198]
Pages: 12
DOI: 10.2174/187152510792481199
Price: $65

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