Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

Author(s): Hongwen He, Weiguo Dong, Fang Huang

Journal Name: Current Neuropharmacology

Volume 8 , Issue 3 , 2010

Become EABM
Become Reviewer


Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in AD. Melatonin is a secretory product of the pineal gland; melatonin is a potent antioxidant and free radical scavenger and may play an important role in aging and AD. Melatonin decreases during aging and patients with AD have a more profound reduction of this indoleamine. Additionally, the antioxidant properties, the anti-amyloidogenic properties and anti-apoptotic properties of melatonin in AD models have been studied. In this article, we review the antiamyloidogenic and anti-apoptotic role of melatonin in AD.

Keywords: Alzheimer disease, neurodegeneration, neuroprotection, melatonin, amyloid beta-protein, amyloid precursor protein, apoptosis, mitochondria

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [211 - 217]
Pages: 7
DOI: 10.2174/157015910792246137
Price: $65

Article Metrics

PDF: 4