Understanding the Role of Aldose Reductase in Ocular Inflammation

Author(s): U.C.S. Yadav, S.K. Srivastava, K.V. Ramana

Journal Name: Current Molecular Medicine

Volume 10 , Issue 6 , 2010

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Abstract:

Aldose reductase, although identified initially as a glucose-reducing enzyme via polyol pathway, is believed to be an important component of antioxidant defense system as well as a key mediator of oxidative stress-induced molecular signaling. The dual role played by AR has made it a very important enzyme for the regulation of not only the cellular redox state by detoxifying the reactive lipid-aldehydes generated by lipid peroxidation which is crucial in the cellular homeostasis, but also in the regulation of molecular signaling cascade that may regulate oxidative stress-induced cytotoxic events. Search for the new molecular targets to restrain the oxidative stress-induced inflammation has resulted in the identification of AR as an unanticipated mediator of oxidative stress-induced signaling. Although, in last one decade or so AR has been implicated in various inflammation-related disease conditions ranging from diabetes, sepsis, cancer, cardiovascular and airway inflammation, however, a critical evaluation of the clinical efficacy of AR inhibitors awaits a better understanding of the role of AR in regulating inflammation, especially in ocular inflammation.

Keywords: Aldose reductase, inflammation, uveitis, NF-κB, GS-DHN, infection, autoimmunity

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2010
Page: [540 - 549]
Pages: 10
DOI: 10.2174/1566524011009060540
Price: $65

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