FOXP3: Required but Not Sufficient. The Role of GARP (LRRC32) as a Safeguard of the Regulatory Phenotype

Author(s): M. Probst-Kepper, R. Balling, J. Buer

Journal Name: Current Molecular Medicine

Volume 10 , Issue 6 , 2010

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Abstract:

FOXP3 is essential for the development and function of regulatory CD4+CD25hi T (Treg) cells. However, recent evidence suggests that FOXP3 alone is not sufficient to completely explain the regulatory phenotype of these key players in autoimmunity and inflammation: after being activated, conventional human CD4+ T cells transiently up-regulate FOXP3 without acquiring a regulatory function. Researchers have recently found that glycoprotein A repetitions predominantly (GARP, or LRRC32) is a Treg-specific receptor that binds latent TGF-β and dominantly controls FOXP3 and the regulatory phenotype via a positive feedback loop. This finding provides a missing link in our molecular understanding of FOXP3 in Treg cells. This viewpoint focuses on GARP as safeguard of FOXP3 and the regulatory phenotype.

Keywords: Regulatory T cells, FOXP3, GARP, TGF-β, LAP, positive feedback

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2010
Page: [533 - 539]
Pages: 7
DOI: 10.2174/1566524011009060533
Price: $65

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