Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression

Author(s): M. Beatriz Currier, Charles B. Nemeroff

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 9 , Issue 3 , 2010

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Increasing evidence suggests that activation of the innate immune system may play a seminal role in the pathophysiology of depression. Several lines of evidence support the association of inflammation and depression. Peripheral administration of cytokines, such as interferon-alpha, can induce many of the symptoms of the depressive syndrome. In addition, medically healthy patients with major depression exhibit elevated plasma levels of proinflammatory cytokines. Moreover, cytokines produce effects on a variety of neurobiological substrates previously implicated in the pathogenesis of depression. Thus, proinflammatory cytokines alter neuroendocrine function, several neurotransmitter systems including dopamine and glutamate, neural plasticity, and neuronal activity in limbic regions. The burgeoning evidence that depression is an inflammatory disease is reviewed.

Keywords: Inflammation, cytokines, depression, monoamine neurotransmitters, hypothalamic-pituitary-adrenal axis, glutamate.

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Article Details

Year: 2010
Page: [212 - 220]
Pages: 9
DOI: 10.2174/1871523011009030212
Price: $65

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