Stability and Drug Metabolism Assessed by Electrochemical Methods

Author(s): Alejandro Alvarez-Lueje, Soledad Bollo Dragnic

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 8 , 2010


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Abstract:

This review is focused on the use of the electrochemical techniques, voltammetry and polarography, as well as biosensors, for the study of drug stability. In addition, this review also details the study of drug metabolism by electrochemistry and mass spectrometry. This is used as a tool to mimic drug metabolism and because it is a purely instrumental method, may have advantages over, or be complementary to, the existing biological assays.

Keywords: Drug, stability, metabolism, voltammetry, polarography, biosensors, electrochemistry-mass spectrometry

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2010
Page: [712 - 727]
Pages: 16
DOI: 10.2174/138620710791920329
Price: $65

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