Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors

Title: Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors

Volume: 13 Issue: 8

Author(s): Raluca-Ioana Stefan van Staden, Nontete Suzan Nhlapo, Jacobus Frederick van Staden and Hassan Y. Aboul-Enein

Affiliation:

Keywords: Enantioselective, potentiometric membrane electrode, (-) butaclamol, vancomycin, teicoplanin

Abstract: Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10-10 and 10-7 mol/L and between 10-9 and 10-7 mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.

Cite this article as:

Stefan van Staden Raluca-Ioana, Suzan Nhlapo Nontete, Frederick van Staden Jacobus and Y. Aboul-Enein Hassan, Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors, Combinatorial Chemistry & High Throughput Screening 2010; 13 (8) . https://dx.doi.org/10.2174/138620710791920301