Use of the Adamantane Structure in Medicinal Chemistry

Author(s): Guy Lamoureux, Graciela Artavia

Journal Name: Current Medicinal Chemistry

Volume 17 , Issue 26 , 2010

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This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.

Keywords: Adamantane, hydrophobic effects, ion channels, rigid scaffold

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Article Details

Year: 2010
Page: [2967 - 2978]
Pages: 12
DOI: 10.2174/092986710792065027
Price: $65

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PDF: 66