Abstract
This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.
Keywords: Adamantane, hydrophobic effects, ion channels, rigid scaffold
Current Medicinal Chemistry
Title: Use of the Adamantane Structure in Medicinal Chemistry
Volume: 17 Issue: 26
Author(s): Guy Lamoureux and Graciela Artavia
Affiliation:
Keywords: Adamantane, hydrophobic effects, ion channels, rigid scaffold
Abstract: This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.
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Cite this article as:
Lamoureux Guy and Artavia Graciela, Use of the Adamantane Structure in Medicinal Chemistry, Current Medicinal Chemistry 2010; 17 (26) . https://dx.doi.org/10.2174/092986710792065027
DOI https://dx.doi.org/10.2174/092986710792065027 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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