Combination of Electrochemical, Spectrometric and Other Analytical Techniques for High Throughput Screening of Pharmaceutically Active Compounds

Author(s): Sibel Suzen, Sibel A. Ozkan

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 7 , 2010


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Abstract:

Recently, the use of electrochemistry and combination of this method with spectroscopic and other analytical techniques are becoming one of the important approaches in drug discovery and research as well as quality control, drug stability, determination of physiological activity, and measurement of neurotransmitters. Many fundamental physiological processes depend on oxido-reduction reactions in the body. Therefore, it may be possible to find connections between electrochemical and biochemical reactions concerning electron transfer pathways. Applications of electrochemical techniques to redox-active drug development and studies are one of the recent interests in drug discovery. In this review, the latest developments related to the use of electrochemical techniques in drug research will be surveyed in order to evaluate possible combinations of spectrometric methods with electrochemical techniques.

Keywords: Electrochemistry, voltammetry, mass spectrometry, HPLC, chemiluminescence

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Article Details

VOLUME: 13
ISSUE: 7
Year: 2010
Published on: 01 March, 2012
Page: [658 - 664]
Pages: 7
DOI: 10.2174/1386207311004070658
Price: $65

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