Graphite-Epoxy Electrodes Modified with Functionalised Carbon Nanotubes and Chitosan for the Rapid Electrochemical Determination of Dipyrone

Author(s): Rasa Pauliukaite, Mariana Emilia Ghica, Orlando Fatibello-Filho, Christopher M.A. Brett

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 7 , 2010

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A rapid electrochemical procedure for the determination of dipyrone was successfully developed at a carbon nanotube modified graphite-epoxy resin composite (GrEC) electrode. The composite electrode was used as support on which multi-walled carbon nanotubes (MWCNT) were immobilised by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide together with N-hydroxysuccinimide (EDC-NHS) in a chitosan (Chit) matrix. The electrochemical behaviour of dipyrone at this electrode in different buffer electrolytes with pH values between 5.0 and 8.0 was explored using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy, and comparison with a conventional glassy carbon electrode was made. Dipyrone was best determined by differential pulse voltammetry with a low limit of detection of 1.4 μM. Application to commercial samples was demonstrated.

Keywords: Dipyrone, functionalised carbon nanotubes, cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy

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Article Details

Year: 2010
Page: [590 - 598]
Pages: 9
DOI: 10.2174/1386207311004070590
Price: $65

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