Abstract
Squamous cell carcinoma of anal canal (SCCA) and its precursor lesions are increasing in prevalence for the diffusion of human papillomavirus infection. The treatment of the cancer of the anal canal represents a model for the application of organ sparing, combined modality therapy for curative treatment. Squamous cell carcinoma of anal canal was originally a surgically treated disease that required Abdominoperineal Resection (APR), approximately two thirds of patients are now cured with a combination of chemotherapy and radiation with sphincter preservation. This article reviews randomized trials and recent studies on chemoradiation for anal cancer.
Keywords: Anal cancer, radiotherapy, chemotherapy
Current Drug Therapy
Title: The Association of Chemotherapy and Radiotherapy in Squamous Cell Carcinoma of Anal Canal
Volume: 5 Issue: 3
Author(s): Francesca Valvo, Barbara Avuzzi and Federico Bozzetti
Affiliation:
Keywords: Anal cancer, radiotherapy, chemotherapy
Abstract: Squamous cell carcinoma of anal canal (SCCA) and its precursor lesions are increasing in prevalence for the diffusion of human papillomavirus infection. The treatment of the cancer of the anal canal represents a model for the application of organ sparing, combined modality therapy for curative treatment. Squamous cell carcinoma of anal canal was originally a surgically treated disease that required Abdominoperineal Resection (APR), approximately two thirds of patients are now cured with a combination of chemotherapy and radiation with sphincter preservation. This article reviews randomized trials and recent studies on chemoradiation for anal cancer.
Export Options
About this article
Cite this article as:
Valvo Francesca, Avuzzi Barbara and Bozzetti Federico, The Association of Chemotherapy and Radiotherapy in Squamous Cell Carcinoma of Anal Canal, Current Drug Therapy 2010; 5 (3) . https://dx.doi.org/10.2174/157488510791561093
DOI https://dx.doi.org/10.2174/157488510791561093 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Raman Spectroscopy-based Metabonomics of HIV-infected Sera Detects Amino Acid and Glutathione Changes
Current Metabolomics Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines
Current Pharmaceutical Design The Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors
Current Drug Metabolism Application of Novel Nanotechnology Strategies in Plant Biotransformation: A Contemporary Overview
Recent Patents on Biotechnology Clinical and Forensic Signs Related to Cocaine Abuse
Current Drug Abuse Reviews Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders
Current Pharmaceutical Design Towards Computational Models of Identifying Protein Ubiquitination Sites
Current Drug Targets Trifluoroibuprofen Inhibits α-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits in vivo Tumor Growth in Aggressive Prostate Cancer Models
Anti-Cancer Agents in Medicinal Chemistry The Role of Atelocollagen-Based Cell Transfection Array in High- Throughput Screening of Gene Functions and in Drug Discovery
Current Drug Discovery Technologies Synthesis of 2-(Bis (2-Chloroethyl)Amino)-N-(5-Substitutedphenyl)- 1,3,4- Thiadiazol-2-Yl)Acetohydrazide And Evaluation of Anticancer Activity
Current Bioactive Compounds Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells
Current Cancer Therapy Reviews Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Involvement of Cytoskeleton in AhR-Dependent CYP1A1 Expression
Current Drug Metabolism The Potential Role of Radiation Therapy in Bowens Disease: A Review of the Current Literature
Reviews on Recent Clinical Trials Structural Modeling Studies of Aldehyde Dehydrogenase X: Insights into Key Interactions in the Tetrameric Assembly of the Isoenzyme
Protein & Peptide Letters 99mTc-HYNIC-D4 Peptide: A New Small Radiolabeled Peptide for Non Small Cell Lung Tumor Targeting
Anti-Cancer Agents in Medicinal Chemistry Plant Proteinases and Inhibitors: An Overview of Biological Function and Pharmacological Activity
Current Protein & Peptide Science Medicinal Importance, Pharmacological Activities and Analytical Aspects of Canadine in Medicine: An Important Phytochemical of <i>Hydrastis canadensis</i>
Current Chinese Chemistry Nanomaterial Based Affinity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria
Recent Patents on Nanotechnology Proteome Analysis in Hematology Using Capillary Electrophoresis Coupled On-Line to Mass Spectrometry
Mini-Reviews in Medicinal Chemistry