Chiral Analyses at Nano-Scale

Author(s): Imran Ali, Zeid A. AL-Othman, Kishwar Saleem, Hassan Y. Aboul-Enein

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 6 , 2010

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Nano scale chiral separation is essential and has become the demand of current century in drugs development, proteomic, genomic and environmental sciences. Some drugs remain in our body tissues for several weeks at nano scale, which are out of the domain of detection by conventional analytical methods. Similarly, the analyses and detection of xenobiotics; present at nano or low levels; are essential for our health. The present review describes the state-of-art of nano scale chiral separations by nano liquid chromatography (NLC) and nano capillary electrophoresis (NCE). The optimization strategies of chiral separations have been also discussed. Furthermore, efforts were made to discuss the mechanisms of chiral separations in NLC and NCE.

Keywords: Nano scale chiral separations, liquid chromatography (NLC) and nano capillary electrophoresis (NCE), chiral recognition mechanisms

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Article Details

Year: 2010
Page: [562 - 567]
Pages: 6
DOI: 10.2174/138620710791515950
Price: $65

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