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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

Author(s): Birke Dejaegher, Sigrid Pieters, Yvan Vander Heyden and Bieke Dejaegher

Volume 13, Issue 6, 2010

Page: [530 - 547] Pages: 18

DOI: 10.2174/138620710791516030

Price: $65

Abstract

In this review paper, the high throughput potential of some novel chromatographic modes is surveyed. The modes are Hydrophilic Interaction Liquid Chromatography (HILIC), Supercritical Fluid Chromatography (SFC), and Polar Organic Solvent Chromatography (POSC). Their high throughput potential will be discussed in three domains, i.e. drug discovery, bio-analysis in clinical drug development, and quality control (QC) testing, and is illustrated with some examples.

Keywords: Hydrophilic interaction liquid chromatography (HILIC), supercritical fluid chromatography (SFC), polar organic solvent chromatography (POSC)


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