Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

Author(s): Birke Dejaegher, Sigrid Pieters, Yvan Vander Heyden, Bieke Dejaegher

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 6 , 2010

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In this review paper, the high throughput potential of some novel chromatographic modes is surveyed. The modes are Hydrophilic Interaction Liquid Chromatography (HILIC), Supercritical Fluid Chromatography (SFC), and Polar Organic Solvent Chromatography (POSC). Their high throughput potential will be discussed in three domains, i.e. drug discovery, bio-analysis in clinical drug development, and quality control (QC) testing, and is illustrated with some examples.

Keywords: Hydrophilic interaction liquid chromatography (HILIC), supercritical fluid chromatography (SFC), polar organic solvent chromatography (POSC)

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Article Details

Year: 2010
Page: [530 - 547]
Pages: 18
DOI: 10.2174/138620710791516030
Price: $65

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