In Vivo Gamma Scintigraphic Evaluation and Determination of a Gastro-Resistant Etodolac Tablet in Humans

Author(s): Yalcin Ozkan, Timurhan Ceyhan, Nuri Arslan, Yavuz Narin, Askin Isimer

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 13 , Issue 6 , 2010

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A gastro-resistant (enteric coated) etodolac tablet dosage form, was evaluated by using in vitro and in vivo methods. In vitro drug release studies have shown that enteric coated tablet dosage form protects the drug from being released under conditions mimicking stomach to small intestine transit. The gastro-intestinal transit of radiolabeled 300 mg enteric coated etodolac tablets in six healthy, fed and fasted state voluntrees was monitored using external gamma camera. Dosage form position was reported at several time intervals. Etodolac serum concentrations were determined from serum samples drawn over 420 min following dosing. Differences in gastro-intestinal transit between fed and fasted volunteers had little effect on etodolac bioavailability. AUC, Tmax and C max values were calculated for both types of studies.

Keywords: Gamma scintigraphy, bioavailability, etodolac, gastro-resistant tablets, gastrointestinal transit

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Article Details

Year: 2010
Page: [490 - 496]
Pages: 7
DOI: 10.2174/138620710791515833
Price: $65

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