Potential Cancer Gene Therapy by Baculoviral Transduction

Author(s): Shu Wang, Ghayathri Balasundaram

Journal Name: Current Gene Therapy

Volume 10 , Issue 3 , 2010

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Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.

Keywords: Baculovirus, viral vector, transduction, cancer therapy

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Article Details

Year: 2010
Page: [214 - 225]
Pages: 12
DOI: 10.2174/156652310791321251
Price: $65

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