The Pauson-Khand Reaction in the Synthesis of Pharmacologically Active Compounds

Author(s): Jorg Habermann

Journal Name: Current Organic Chemistry

Volume 14 , Issue 11 , 2010

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Abstract:

The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.

Keywords: Pauson-Khand reaction, drug discovery, Diversity-oriented synthesis, target-oriented synthesis

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Article Details

VOLUME: 14
ISSUE: 11
Year: 2010
Page: [1139 - 1152]
Pages: 14
DOI: 10.2174/138527210791317085
Price: $58

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