Abstract
Nanoparticles have long been sought as promising drug delivery system for cancer therapy, including liposomes, polymeric micelles, polymer-drug conjugates, dendrimers and polymeric nanoparticles. However, conventional nanoparticles would be specifically entrapped by the monocyte phagocytic system (MPS), and then quickly eliminated following intravenous administration, so the applications of nanoparticles are limited due to short circulation lifetime. Since long-circulation property is the prerequisite for nanoparticles reaching the target site of interest, the nanoparticle surface is usually modified by hydrophilic polymer materials such as PEG, to reduce plasma opsonization and MPS uptake. Furthermore, increased tumor specificity and cell internalization will improve the treatment efficacy and decrease the serious side effects for many cytotoxic antineoplastic drugs. Introducing the targeting ligands for interaction with specific tumor cells or tissues will offer major enhancement in cancer therapeutics via site specificity, reduction of multidrug resistance and improved delivery efficiency. This article will give an overview on the current state of long-circulating nanoparticles and describe their major advantages and potential pitfalls. Special emphasis is placed on the superiority of long-circulating nanoparticles used for tumor targeting.
Keywords: Nanoparticles, targeted drug delivery, long-circulating nanoparticles, cancer therapy
Current Nanoscience
Title: Long-circulating Targeted Nanoparticles for Cancer Therapy
Volume: 6 Issue: 4
Author(s): Yang Liu, Jin Sun, Jihong Han and Zhonggui He
Affiliation:
Keywords: Nanoparticles, targeted drug delivery, long-circulating nanoparticles, cancer therapy
Abstract: Nanoparticles have long been sought as promising drug delivery system for cancer therapy, including liposomes, polymeric micelles, polymer-drug conjugates, dendrimers and polymeric nanoparticles. However, conventional nanoparticles would be specifically entrapped by the monocyte phagocytic system (MPS), and then quickly eliminated following intravenous administration, so the applications of nanoparticles are limited due to short circulation lifetime. Since long-circulation property is the prerequisite for nanoparticles reaching the target site of interest, the nanoparticle surface is usually modified by hydrophilic polymer materials such as PEG, to reduce plasma opsonization and MPS uptake. Furthermore, increased tumor specificity and cell internalization will improve the treatment efficacy and decrease the serious side effects for many cytotoxic antineoplastic drugs. Introducing the targeting ligands for interaction with specific tumor cells or tissues will offer major enhancement in cancer therapeutics via site specificity, reduction of multidrug resistance and improved delivery efficiency. This article will give an overview on the current state of long-circulating nanoparticles and describe their major advantages and potential pitfalls. Special emphasis is placed on the superiority of long-circulating nanoparticles used for tumor targeting.
Export Options
About this article
Cite this article as:
Liu Yang, Sun Jin, Han Jihong and He Zhonggui, Long-circulating Targeted Nanoparticles for Cancer Therapy, Current Nanoscience 2010; 6 (4) . https://dx.doi.org/10.2174/157341310791658991
DOI https://dx.doi.org/10.2174/157341310791658991 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cellular Therapy for Heart Failure
Current Cardiology Reviews Neurodevelopmental Delay and Intellectual Disability in Pediatric Heart Transplant
Current Psychiatry Reviews Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
Current Pharmaceutical Design Late-Onset Glycogen Storage Disease Type 2
Current Molecular Medicine The Emerging Role of Vascular Endothelial Growth Factor (VEGF) in Vascular Homeostasis: Lessons from Recent Trials with Anti-VEGF Drugs
Current Vascular Pharmacology Phosphodiesterase-5 Inhibitors: Future Perspectives
Current Pharmaceutical Design Oxidative Stress on Progenitor and Stem Cells in Cardiovascular Diseases
Current Pharmaceutical Biotechnology Genetics of Ion Channels in Sudden Unexplained Death Syndrome: Moving Beyond Idiopathic Reactions To Personalized Risk Assessment
Current Pharmacogenomics and Personalized Medicine Endothelial Microparticles: Mediators or Markers of Endothelial Cell Dysfunction?
Current Hypertension Reviews Efficacy and Safety of Mesenchymal Stem Cell Therapy in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Current Stem Cell Research & Therapy Co-formulation of P-glycoprotein Substrate and Inhibitor in Nanocarriers: An Emerging Strategy for Cancer Chemotherapy
Current Cancer Drug Targets Vanilloid Receptor Antagonists: Emerging Class of Novel Anti-Inflammatory Agents for Pain Management
Current Pharmaceutical Design Reactive Oxygen and Nitrogen Species in the Renal Ischemia/Reperfusion Injury
Current Pharmaceutical Design Stress, Cardiovascular Diseases and Surgery-Induced Angiogenesis
Current Angiogenesis (Discontinued) Clinical Management of the Cardiovascular Failure in Sepsis
Current Vascular Pharmacology Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease
Current Vascular Pharmacology Single-cell RNA Sequencing: In-depth Decoding of Heart Biology and Cardiovascular Diseases
Current Genomics New Perspective Therapy of Breast Cancer Based on Selective Dopamine Receptor D2 Agonist and Antagonist Effects on MCF-7 Cell Line
Recent Patents on Anti-Cancer Drug Discovery Nanotechnology and Diabetic Wound Healing: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Subject Index To Volume 2
Current Cardiology Reviews