Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus

Author(s): Xiaoli Guo, Jing-Fang Wang, Yisheng Zhu, Dong-Qing Wei

Journal Name: Current Computer-Aided Drug Design

Volume 6 , Issue 2 , 2010

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Design of novel H5N1 inhibitors is currently a research topic of vital importance owing to both a recent pandemic threat by the worldwide spread of H5N1 avian influenza and the high resistance of H5N1 virus to the most widely used commercial drug, oseltamivir-OTV (Tamiflu). There has been much progress in this field recently. This review covers recent work on bioinformatics studies, structure based design, computer modeling and molecular dynamics simulations.

Keywords: M2-ion channel inhibitors, NA inhibitors, H5N1 viruses, drug-resistance, adamantanes, oseltamivir, structure-based drug design

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Article Details

Year: 2010
Page: [139 - 146]
Pages: 8
DOI: 10.2174/157340910791202487
Price: $65

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