Reasons for Physicians Choice of Medication in Medication-Naive Patients with ADHD: Baseline Data from the COMPLY Observational Study

Author(s): Peter M. Wehmeier, Alexander Schacht, Ralf W. Dittmann, Tobias Banaschewski

Journal Name: Current Drug Therapy

Volume 5 , Issue 2 , 2010

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Background: The various patient-, parent-, and physician-related factors that influence the choice of a particular medication for attention-deficit/hyperactivity disorder (ADHD) have been insufficiently investigated. The physician-reported reason for choice of medication was one factor assessed in this observational study on compliance with ADHD medication. Methods: This is a baseline data analysis of a multicenter, prospective, 12-month observational study in children and adolescents with ADHD. Among other factors, the physicians reason for choice of medication was captured at baseline.The two largest medication groups (non-stimulants vs. stimulants) were compared in terms of reasons for choice of medication. Correlations were explored by Pearsons correlation coefficient, Cohens Kappa, and cluster analyses. Results: 504 patients with a mean age 9.6 years were included. Non-stimulant medication was prescribed in 50.0% and stimulant medication in 49.0% of patients (1% received both). There were no significant group differences in baseline ADHD symptom scores.Reasons for choosing non-stimulants over stimulants included: “duration of action” (73.4%/28.7%), “beneficial for compliance” (60.3%/40.1%), and “patient/parent decision” (33.7%/26.3%). Reasons for choosing stimulants over non-stimulants included: “good efficacy” (93.1%/73.0%), “good tolerability” (66.4%/44.1%), and “well-priced” (38.1%/2.8%). Conclusion: The reasons for choice of medication reported by physicians differed significantly between the two medication groups. Trial Registration Number: Identifier: NCT00540826.

Keywords: Reason for choice of medication, ADHD, observational study, stimulants, atomoxetine

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [139 - 150]
Pages: 12
DOI: 10.2174/157488510791065076
Price: $65

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